Glycoin® Bitop AG - All rights reserved

Glyceryl Glucoside

  • Found in the Ressurection Plant
  • Improves skin structure and enhances tissue repair
  • Natural cell-energizer, enhances cellfunctions
  • Enhances wound healing

1 - Ex Vivo

Wound Healing Benefits

Protocol

  • Ex vivo skin model; surface was mechanically reduced by 3mm (loss of epidermis and dermis)
  • Immediately after wound making, wound spot was covered with 5μ pBS with 2,38% Glycoin natural and without (placebo)
  • Incubator for 48h in cell incubator
  • Hematoxylin/eosin staining of skin model for evaluation

Results

Glycoin® natural treated wounds show excellent and faster healing after 48h in comparison to placebo treated control.

2 - In Vitro

Protocol

  • cDNA array for gene expression of human dermal fibroblasts incubated with 1% Glycoin® natural
  • Incubation for 96h
  • Measured parameters: ROS scavenger CAT, SOD2 and TRDX

Results

Increased expression of CAT, SOD and TRDX after treatment with Glycoin® natural.

3 - In Vitro

Protocol

  • cDNA array for gene expression of human dermal fibroblasts incubated with 1% Glycoin® natural
  • Incubation for 96h
  • Measured parameters: Growt factors FGF 7 & TGF-beta 1

Results

Increased expression of the wound healing related growth factors FGF 7 (fibroblast growth factor) and TGF-beta 1 (transforming growth factor beta-1) and treatment with 1% Glycoin natural.

Increase of cell viability

Protocol

  • The cell viability of NHEKs cultivated in the presence and absense of Glycoin® natural (1%) was conducted in te same experimental setup.

Results

Cells which had been cultivated in the presence of Glycoin® naturally showed considerably higher metabolic activity than those which had been treated with the control. The cell metabolism per cell enhanced by up to 170%

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